通过重复的大规模抗生素治疗来消除眼球菌的可行性
Muluken Melese1, Jaya Devi Chidambaram, Wondu Alemayehu
1ORBIS International, Addis Ababa, Ethiopia.
JAMA
|August 12, 2004
概括
大规模的抗生素治疗可以消除眼球性克拉米迪亚,这是控制气管瘤的关键目标. 两年一次的治疗是足够频繁的,以清除社区的感染,支持公共卫生工作.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 大规模的抗生素管理对于世界卫生组织的气管瘤控制计划至关重要.
- 数学模型表明,随着覆盖范围,频率和再感染率,在重复的大量治疗下,局部气管瘤消除是可能的.
- 缺乏大规模治疗后感染复发率的估计.
研究的目的:
- 量化眼睛甲状腺炎感染复发率的大规模治疗后的比例.
- 确定必要的治疗频率,以在社区层面消除眼球克拉米迪亚.
主要方法:
- 从2003年2月到10月,在24个埃塞俄比亚村庄进行了一项纵向队列研究.
- 在治疗前和治疗后2个月和6个月内,对1-5岁的1332名儿童进行了眼球甲状腺炎感染流行情况的监测.
- 聚合酶链反应 (PCR) 用于测量感染流行率,估计再感染率和所需的治疗频率.
主要成果:
- 在治疗前感染的患病率为56.3%,在治疗2个月后降至6.7%,在治疗6个月后升至11.0%.
- 眼睛甲状腺炎感染以每月12.3%的指数级速度复发.
- 在80%的覆盖率下,消除的最低治疗频率估计为每11.6个月一次,这表明两年一次的治疗足够.
结论:
- 观察到的眼球甲状腺炎感染复发率支持了在超大流行地区消除的可行性.
- 两年一次的大规模抗生素管理,再加上可实现的覆盖水平,很可能足以消除眼球克拉米迪亚.
- 这些发现加强了当前气管瘤控制策略的有效性.
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