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在遗传性视网膜退行症中,循环GMP二酶激活剂的参与

Y P Liu1, G Krishna, G Aguirre

  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.

Nature
|July 5, 1979
PubMed
概括

No abstract available in PubMed .

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...