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Updated: Jul 10, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

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Published on: November 16, 2011

缺少S6K1可以防止年龄和饮食引起的肥胖,同时增强胰岛素敏感性

Sung Hee Um1, Francesca Frigerio, Mitsuhiro Watanabe

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

Nature
|August 13, 2004
PubMed
概括

S6 激酶1 (S6K1) 缺陷通过增强脂肪分解来防止肥胖. 然而,S6K1对胰岛素信号进行负面调节,特别是在高脂肪条件下,为糖尿病提供了新的治疗点.

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