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相关概念视频

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...

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相关实验视频

Updated: Jul 9, 2026

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

通过SIV包膜糖蛋白gp160的亚单元疫苗保护免受SIV感染.

S L Hu1, K Abrams, G N Barber

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.

Science (New York, N.Y.)
|January 24, 1992
PubMed
概括

复合子单位疫苗表达Simian Immunodeficiency Virus (SIV) 包裹抗原保护子免受SIV感染. 这表明,仅仅病毒包膜蛋白就能引起对灵长类隐形病毒的保护性免疫力.

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Packaging HIV- or FIV-based Lentivector Expression Constructs & Transduction of VSV-G Pseudotyped Viral Particles
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Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
07:10

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

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Last Updated: Jul 9, 2026

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

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Published on: June 23, 2011

Packaging HIV- or FIV-based Lentivector Expression Constructs & Transduction of VSV-G Pseudotyped Viral Particles
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科学领域:

  • 病毒学 病毒学
  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学

背景情况:

  • 类似免疫缺陷病毒 (SIV) 是一种与人类免疫缺陷病毒 (HIV) 相关的晶状病毒.
  • 在中,SIV会引起获得性免疫缺陷综合征 (AIDS) 类疾病.
  • 以前,只有被禁用的整体SIV疫苗才能保护虫免受感染.

研究的目的:

  • 评估复合子单位疫苗在保护子免受SIV的有效性.
  • 为了确定单独的病毒包膜抗原是否足以保护对SIV的免疫力.

主要方法:

  • 四只 Macaca fascicularis 被用一种表达SIVmne gp160.0.的重组疫苗病毒免疫.
  • 动物接受了一次用巴库洛病毒感染细胞中产生的gp160进行增强免疫.
  • 被保护的动物被输入同类SIV.的静脉挑战.

主要成果:

  • 所有四只免疫都被保护免受同类的SIV挑战.
  • 挑战剂量范围从1到9个动物传染剂量.
  • 使用组合免疫治疗方案实现了保护.

结论:

  • 仅用病毒包膜抗原进行免疫接种就足以引起对SIV的保护性免疫力.
  • 这种免疫策略类似于候选人免疫缺陷病毒 (HIV) -1 疫苗,是有效的.
  • 再组合子单位疫苗代表了SIV和潜在的HIV疫苗开发的有希望的方法.