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在全身性硬化症中缺陷血管生成
Masataka Kuwana1, Yuka Okazaki, Hidekata Yasuoka
1Institute for Advanced Medical Research Keio University School of Medicine, Tokyo, Japan. kuwanam@sc.itc.keio.ac.jp
Lancet (London, England)
|August 18, 2004
概括
系统性硬化症患者的循环内皮前体前体较少,损害了血管修复. 这表明有缺陷的血管生成有助于他们的血管疾病,并提供潜在的治疗点.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 系统性硬化症 (SSc) 的特征是血管损伤,包括毛细血管密度降低和血管消灭.
- 血管生成,血管的形成和修复,依赖于循环内皮前体 (CEP).
- 血管生成受损可能是SSc.观察到的血管病理的基础.
研究的目的:
- 调查系统性硬化症患者的血管生成是否受损.
- 与对照人群相比,在SSc患者中量化循环内皮前体 (CEP).
- 评估CEP在SSc中的差异化潜力.
主要方法:
- 在SSc,类风湿性关节炎和健康对照组的周围血液中使用流细胞计量量化CEP (CD34+,CD133+,VEGFR2+).
- 通过ELISA测量循环血管生成因子.
- 通过体外成熟和·威莱布兰德因子表达,评估CEP的差异化能力.
主要成果:
- 与类风湿性关节炎患者和健康对照人群相比,SSc患者的CEP绝对数量明显较低 (p<0.0001).
- 矛盾的是,在SSc患者中,循环血管生成因子度升高.
- 在SSc患者中,能够分化为内皮细胞的CEP的比例显著降低 (p<0.0001).
结论:
- 缺陷血管生成,由CEP的数量减少和差异化受损表明,可能会导致系统性硬化症中出现的血管病变.
- 失调的血管生成可能与其他血管疾病有关,包括癌症和动脉样硬化.
- CEP代表了管理SSc.中缺血并发症的潜在治疗目标.
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