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肌肉纤维模式是独立于细胞系在产后动物发育的细胞系
1Department of Pharmacology, Stanford University School of Medicine, California 94305-5332.
Cell
|February 21, 1992
概括
肌肉纤维模式在发育过程中并不是由肌细胞细胞系决定的. 相反,外部信号引导肌肉纤维的发育,取代了肌细胞的任何内在遗传编程.
科学领域:
- 发育生物学是发展生物学.
- 细胞生物学 细胞生物学
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉纤维在成长中的四肢中表现出明显的快速和缓慢的收缩模式.
- 实验室研究表明,特定的肌细胞系可能决定肌肉纤维类型和模式.
研究的目的:
- 为了调查不同的髓细胞系是否负责建立肌肉纤维模式在体内.
- 为了确定外在信号是否影响肌肉细胞命运和肌肉纤维模式.
主要方法:
- 利用逆转录病毒标签在体内基因标记和追踪单个肌细胞克隆.
- 分析了标记的肌细胞克隆对成长中的肢体内不同类型的肌肉纤维的贡献.
主要成果:
- 肌细胞克隆,无论是在现场标记还是体外培养和移植后,都为所有遇到的肌肉纤维类型提供了后代.
- 证明神经细胞后代不仅仅是根据其起源形成特定的纤维类型.
结论:
- 产后发育中的肌肉纤维模式不是由肌细胞细胞系所决定的.
- 外在环境信号在覆盖内在肌肉细胞编程和确定肌肉纤维类型和模式方面发挥着至关重要的作用.
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