优化糖导向的分子传递到生物受体:设计,合成和生物评价的糖二甲基-环二联合体

Juan M Benito1, Marta Gómez-García, Carmen Ortiz Mellet

  • 1Contribution from the Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092 Seville, Spain.

概括

具有曼诺斯配体的新型树突性β-cyclopodextrin (betaCD) 衍生物对dcetaxel显示出高的药物溶解性. 微妙的结构变化显著影响受体亲和力和超分子组合,以增强莱克结合.

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