维生素E和老年护理院居民的呼吸道感染:一个随机对照试验
Simin Nikbin Meydani1, Lynette S Leka, Basil C Fine
1Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass 02111, USA. simin.meydani@tufts.edu
JAMA
|August 19, 2004
概括
补充维生素E并没有显著减少老年人呼吸道感染. 然而,它显示出对上呼吸道感染,特别是普通感冒的保护作用,这需要进一步研究.
科学领域:
- 老年学是指老年学的学科.
- 营养免疫学 营养免疫学
- 传染性疾病 传染性疾病
背景情况:
- 老年人容易感染呼吸道感染,导致严重的发病率和死亡率.
- 已知维生素E可以增强老年人的免疫反应,但其对感染的临床影响尚不清楚.
研究的目的:
- 调查一年维生素E补充剂对养老院老年居民呼吸道感染的影响.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及33个长期护理机构的617名老年参与者 (年龄≥65岁).
- 参与者每天接受维生素E (200 IU) 或安慰剂,以及必需的维生素和矿物质.
主要成果:
- 维生素E没有显著影响整体,上或下呼吸道感染的发生率或持续时间.
- 在维生素E组中,对于上呼吸道感染,特别是普通感冒,观察到具有统计学意义的保护作用.
- 没有注意到对抗生素使用的显著影响.
结论:
- 每日补充维生素E (200 IU) 在老年养老院居民中没有统计显著地减少下呼吸道感染.
- 观察到维生素E对上呼吸道感染,特别是普通感冒有显著的保护作用,这表明需要进一步调查.
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