腺素在节拍诱导的心力衰竭中引起心肌梗塞
F L Belloni1, J Wang, T H Hintze
1Department of Physiology, New York Medical College, Valhalla 10595.
Circulation
|March 1, 1992
概括
在心力衰竭中,身体失去了阴道律,揭露了腺对减缓心率 (胸心率) 的直接作用. 这项研究表明,腺对失败的心脏有负面的长期影响.
科学领域:
- 心血管生理学心血管生理学
- 心脏电生理学 心脏电生理学
背景情况:
- 腺素通常会导致狗的低血压和反射性心动减速.
- 阴道切割或阻塞透露了通过鼻腔结节抑制的腺素的直接心效应.
研究的目的:
- 为了研究腺对心率的影响,在患有充血性心力衰竭的犬类模型中.
- 测试假设,心力衰竭中阴道声调的丧失揭露了腺的直接负面慢性otropic效应.
主要方法:
- 蒙格勒犬接受了用于血液动力学监测和心室节奏的仪器仪表.
- 一个为期4周的心室节奏调节方案诱导了充血性心力衰竭.
- 在心力衰竭发生之前和期间注射了腺素.
主要成果:
- 随着心力衰竭的进展,腺素诱导的心率增加减少了.
- 在晚期心力衰竭中,腺注射会导致心率显著下降 (心).
- 尽管同时有抑郁剂反应,但这些心效应仍然发生.
结论:
- 在心力衰竭中丧失阴道音调揭示了腺的直接负面慢性热效应.
- 外源性腺直接抑制心脏衰竭中的鼻腔节点功能.
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