慢性心力衰竭中的血内甲蛋白.
J J McMurray1, S G Ray, I Abdullah
1Department of Cardiology, Western Infirmary, Glasgow, UK.
Circulation
|April 1, 1992
概括
患有慢性心力衰竭 (CHF) 的患者表现出循环内皮质素水平升高,内皮质是一种强大的血管收缩性. 在CHF中,这些增加的内甲素度可能在疾病的病理生理学中发挥重要作用.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 神经研究 神经研究
背景情况:
- 内膜蛋白是新发现的,以其血管收缩性质而闻名.
- 慢性心力衰竭 (CHF) 与外周动脉和血管收缩有关.
研究的目的:
- 在被诊断患有慢性心力衰竭 (CHF) 的患者中研究血内末类免疫活性水平.
主要方法:
- 在患有严重心血管衰竭的患者和健康志愿者中测量周围静脉血内甲蛋白度.
- 在运动期间评估内啡林水平.
- 与血中心房性尿素因子,血清尿素和血清肌素的相关性分析.
- 评估内甲蛋白提取的情况.
主要成果:
- 与健康对照组 (6.4 +/- 0.3 pmol/l) 相比,患有严重心血管衰竭的患者表现出显著更高的血内衣素度 (12.4 +/- 0.6 pmol/l).
- 血内甲蛋白水平在任何一组的运动中都没有变化.
- 在CHF患者中,没有发现血内甲蛋白和心房性尿素因子,尿素或肌素之间的显著相关性.
- 在CHF患者中观察到Endothelin的显著脏提取.
结论:
- 在5-40 pmol/l范围内的循环内甲蛋白度被认为是血管活性.
- 在CHF患者中检测到的内甲素水平升高可能对该综合征具有病理生理学意义.
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