在儿科心脏移植后心脏生长
D Bernstein1, S Kolla, M Miner
1Department of Pediatrics, Stanford University, Calif. 94305.
Circulation
|April 1, 1992
概括
儿童心脏移植接受者在移植后三年内表现出正常的心室生长. 然而,持续的左心室和隔膜缩可能会影响长期的全移植功能.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 移植医学 移植医学
- 心脏生理学 心脏生理学
背景情况:
- 评估儿童心脏移植后心脏正常生长对于长期结果至关重要.
- 以前的研究还没有完全阐明这个人群中心脏尺寸的增长模式.
研究的目的:
- 为了评估心脏移植后的儿科患者是否发生正常的心室生长.
- 在早期和晚期随访期间比较心脏尺寸和壁厚.
主要方法:
- 分析了13名儿科心脏移植接受者的心声图数据.
- 为了进行比较,建立了正常的儿科心脏维度百分位数.
- 用学生的配对t测试来评估心脏尺寸和壁厚度随时间变化的变化.
主要成果:
- 心室尺寸 (右心室和左心室) 处于正常范围内,并显示出正常的生长模式.
- 早期的壁面厚度测量经常高于左心室,隔膜和右心室的95百分位.
- 组织学检查显示肌细胞缩,特别是在隔膜中,没有证据表明有解静脉阻塞.
结论:
- 在儿童心脏移植接受者中,正常的心室维度增长可以在3年内实现.
- 观察到持续的左心室,隔膜和右心室缩,可能会影响全移植功能和生长.
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