基于血液氧气水平依赖效应的肌肉输液成像,使用T2准备的稳定状态自由前行磁共振成像
David S Fieno1, Steven M Shea, Yongzhong Li
1Department of Radiology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, Ill., USA.
Circulation
|August 25, 2004
概括
这项研究表明,T(2) 准备的稳定状态自由前行 (SSFP) 血氧水平依赖 (BOLD) MRI可以评估心肌输液储备. 这种技术准确地反映了狗模型中血管扩张期间血液流量的变化.
科学领域:
- 心血管成像 - 心血管成像
- 磁共振成像技术 磁共振成像技术
- 生理学 生理学 生理学
背景情况:
- 评估心肌输液储备对于指导冠状动脉复血管化程序至关重要.
- 血液氧气水平依赖 (BOLD) MRI提供了一种潜在的方法来评估血管扩张期间心肌血流的区域变化.
研究的目的:
- 评估一种新型T(2) 准备的稳定状态自由前行 (SSFP) MRI 序列的有效性,以评估使用BOLD对比的心肌输液储量.
- 为了将MRI衍生的 perfusion 变化与狗模型中的直接血液流量测量相关联.
主要方法:
- 在分级腺注入过程中,使用1.5TMRI扫描仪与T(2) 准备的SSFP序列对13只狗进行了成像.
- 用光微球评估心肌输液,并分析不同冠状动脉区域的信号强度变化.
- 图像采集包括短轴和长轴心脏切片,在平面分辨率大约为1毫米.
主要成果:
- 用T(2) 准备的SSFP BOLD成像显示了信号强度的变化,这与区域血管扩张和心肌输液储备的改变有关.
- 在最大血管扩张时,LCx和LAD区域之间的信号强度比增加了33+/-4%,与相对 perfusion 增加了3.8倍相关 (P<0.01).
- 磁力共振成像信号强度的变化与微球测量的血液流量有很好的一致性 (R=0.80,P<0.01).
结论:
- 用T(2) 准备的SSFP BOLD成像是一种有前途的非侵入性技术,用于确定心肌 perfusion reserve 的指数.
- 该方法显示了临床应用的潜力,用于评估冠状动脉疾病和指导治疗决策.
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