使用酸基的区域和化学选择性直接生成功能化芳香化合物
Masanobu Uchiyama1, Hiroshi Naka, Yotaro Matsumoto
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. uchiyama@mol.f.u-tokyo.ac.jp
Journal of the American Chemical Society
|August 26, 2004
概括
一种新的直接正体照明方法产生了功能化的芳香化合物. 这种方法可以有效地形成C-C键,用于复杂分子合成.
科学领域:
- 有机金属化学 有机金属化学
- 合成有机化学 合成有机化学
背景情况:
- 定向整形照明是功能化芳香环的强大工具.
- 现有的方法往往需要严苛的条件或特定的指导小组.
研究的目的:
- 开发一种新的,区域选择性和化学选择性直接方法来产生功能化的芳香化合物.
- 探索这些中间体在随后的C-C键形成反应中的实用性.
主要方法:
- 在THF中制备三聚 (iBu3Al) 和四聚 (LTMP) 的三聚 (iBu3Al) 和四聚 (LTMP) 的三聚 (iBu3Al) 和四聚 (TMP) 的三聚 (iBu3Al) 的三聚 (iBu3Al) 的三聚 (iBu3Al) 的三聚 (iBu3Al) 的三聚 (iBu3Al) 的制备.
- 功能化和异芳剂的反定向整形发光.
- 用 (I2) 捕获产生的中间体的电友性捕获 (I2).
- 使用功能化芳香酸盐的铜和催化交叉合反应.
主要成果:
- 成功地生成了正位功能化的芳香和异芳香衍生物,包括含有蓝,胺基和基的衍生物.
- 1,2-和1,2,3-多替代芳香化合物的高效合成,通过直接化和电友性捕获.
- 使用中间体的铜和催化C-C键形成反应的高效率和选择性.
结论:
- 开发的iBu3Al(TMP) Li试剂提供了一种通用且有效的直接正体照明的途径.
- 这种方法为各种功能化的芳香化合物提供了方便的途径.
- 产生的中间体是复杂分子合成中C-C键形成的有价值的前体.
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