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对UDP-galactopyranose突变酶的抑制剂的鉴定

Michelle Soltero-Higgin1, Erin E Carlson, John H Phillips

  • 1Departments of Biochemistry and Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|August 26, 2004
PubMed
概括

研究人员选了1.6万种化合物,以寻找尿素5'-二酸盐 (UDP) - 银酸酶突变酶 (UGM) 的抑制剂,这是Mycobacterium结核病细胞壁合成中的关键酶. 这项研究确定了有效的UGM抑制剂,用于潜在的治疗开发.

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相关概念视频

Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.