调节血管生成:更多或少
Branavan Sivakumar1, Lorraine E Harry, Ewa M Paleolog
1Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London.
JAMA
|August 26, 2004
概括
本综述探讨了血管生成,即新血管的生长,作为治疗策略. 虽然最初对治疗癌症和心血管疾病等疾病的热情很高,但目前的研究表明需要更有针对性的方法.
科学领域:
- 生物医学研究的研究.
- 血管生物学 血管生物学
- 治疗目标 治疗目标
背景情况:
- 血管新生,即新血管的形成,是一种复杂的生物过程,对各种疾病有重大影响.
- 对血管化的操纵已经引起了治疗干预的大量兴趣.
研究的目的:
- 审查血管新生作为癌症和关节炎等疾病的治疗点.
- 探索促进心血管疾病和骨折愈合中的血管生成策略.
主要方法:
- 专注于治疗性血管生成的文献综述.
- 对基于血管生成的治疗方法的临床试验结果的分析.
- 检查血管新生在疾病病理和愈合过程中的作用.
主要成果:
- 血管新生作为一种通用治疗剂的早期热情,特别是对于瘤和糖尿病视网膜病变和类风湿性关节炎等疾病,已经被临床试验结果所缓和.
- 对心血管疾病的治疗性血管生成试验产生了令人失望的结果.
- 血管生成的复杂性需要向更精细和更有针对性的治疗策略迈进.
结论:
- 虽然不是万能药,但血管新生仍然是开发向治疗的有前途领域.
- 需要进一步的研究来克服挑战,并优化血管新生调节的临床应用.
- 精准医学方法有可能利用血管生成的好处来治疗一系列疾病.
相关概念视频
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Overview of Blood Vessels
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Structure of Blood Vessels
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Arteries and Arterioles
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Autoregulation of Blood Flow
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...


