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Updated: Jul 14, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Published on: July 5, 2019

通过致白血病的AML1-ETO融合蛋白对E蛋白进行沉默

Jinsong Zhang1, Markus Kalkum, Soichiro Yamamura

  • 1Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Science (New York, N.Y.)
|August 31, 2004
PubMed
概括

在急性髓性白血病 (AML) 中,AML1-ETO融合蛋白通过防止协激活剂结合来阻断E蛋白的功能. 这种相互作用破坏了正常的基因调节,导致白血病的发展.

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