相关实验视频
Updated: Jun 25, 2026
10:05
High-throughput Detection Method for Influenza Virus
Published on: February 4, 2012
用奥塞尔塔米维尔治疗的儿童中耐药性流感A病毒:描述性研究
Maki Kiso1, Keiko Mitamura, Yuko Sakai-Tagawa
1Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Lancet (London, England)
|September 1, 2004
概括
耐奥塞塔米维尔病毒的流感突变在儿童中比以前认为的更为常见. 儿童即使经过五天的治疗,也可以传播这些耐药病毒.
科学领域:
- 病毒学 病毒学
- 抗病毒耐药性 抗病毒耐药性
- 儿童传染病 儿童传染病
背景情况:
- 奥塞塔米维尔是流感治疗中的关键神经氨基酶抑制剂.
- 在临床使用期间,儿童对奥塞塔米维尔耐药性的数据有限.
- 这项研究解决了理解儿童流感病例中耐药性发展的差距.
研究的目的:
- 为了调查小儿流感患者中奥塞尔塔米维尔耐药性的出现.
- 描述赋予耐药性的特定突变.
- 为了评估治疗儿童的病毒泄露的持续时间.
主要方法:
- 在oseltamivir治疗前和治疗期间,对50名儿童的A型流感 (H3N2) 病毒进行了分析.
- 神经氨基酶和血凝素基因的测序.
- 对突变神经氨基酶对奥塞塔米维尔碳酸盐的表型测试.
主要成果:
- 在18%的患者中发现了赋予耐药性的神经aminidase突变.
- 常见的突变包括Arg292Lys,Glu119Val和Asn294Ser,显著增加了耐药性.
- 从治疗的第4天开始,检测到对奥塞塔米维尔耐药的病毒.
结论:
- 抗奥塞塔米维尔抗性流感突变在儿童中出现的频率比以前报告的更高.
- 儿童可以作为传染耐药性流感菌株的来源.
- 这些发现凸显了监测儿科患者抗病毒耐药性的必要性.
相关概念视频
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...