Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sympathetic Activation01:16

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reducing cardiovascular risk in Belgium through practical and measurable initiatives: a multidisciplinary expert-led call to action.

Acta cardiologica·2026
Same author

Less severe endothelial injury and vascular pathway activation in SARS-CoV-2 Omicron variant compared to Alpha.

Scientific reports·2026
Same author

Diagnostic and management dilemmas in pulmonary hypertension.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Circulating Biomarker Results From a Phase 2 Study of Seralutinib in Pulmonary Arterial Hypertension.

American journal of respiratory and critical care medicine·2026
Same author

Heart rate variability during wakefulness reflects sleep apnea indicators but remains context-dependent.

Frontiers in physiology·2026
Same author

Sotatercept for Combined Post- and Precapillary Pulmonary Hypertension Associated With Heart Failure: Results From the Phase 2, Randomized, Placebo-Controlled CADENCE Study.

Circulation·2026

相关实验视频

Updated: Jun 18, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

在肺动脉高血压中增加了交感神经活动.

Sonia Velez-Roa1, Agnieszka Ciarka, Boutaina Najem

  • 1Department of Cardiology, Erasme University Hospital, Brussels, Belgium. svelezro@ulb.ac.be

Circulation
|September 1, 2004
PubMed
概括

在肺动脉高血压 (PAH) 中,交感神经活动升高. 这种过度活跃部分是由化学反应驱动的,并且与疾病严重程度有关,为PAH病理生理学提供了新的见解.

科学领域:

  • 心血管生理学心血管生理学
  • 呼吸系统医学 呼吸系统医学
  • 神经科学是一个神经科学.

背景情况:

  • 肺动脉高血压 (PAH) 是一种罕见的疾病,预后不佳,病理生理不清楚.
  • 这项研究研究了PAH患者的交感神经活动.

研究的目的:

  • 测试这种假设,即在肺动脉高血压 (PAH) 中,交感神经活动增加.
  • 探索化学反射激活在与PAH相关的同情激发中的作用.

主要方法:

  • 用微神经图测量肌肉交感神经活动 (MSNA) 在17名PAH患者和12名对照组中.
  • 评估了心脏功能,运动能力和化学反应反应.
  • 在交叉设计中,使用100%氧气诱导了外围化学反射失活.

主要成果:

  • 与对照组相比,PAH患者的MSNA和心率显著增加.
  • MSNA与疾病严重性标志物相关,包括NYHA类和氧和度.
  • 在PAH患者中,外周化学反射失活与高氧减少MSNA.

结论:

  • 这项研究提供了第一个直接证据,证明了晚期PAH中交感神经流量的增加.

更多相关视频

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

相关实验视频

Last Updated: Jun 18, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

  • 在PAH中,交感性过活性在一定程度上是由化学反射介导的.
  • 交感性过度活跃可能是PAH严重程度的重要因素.