慢性可卡因滥用者与左心室缩症的慢性可卡因滥用者对跑步机运动的过度压力反应
C G Cigarroa1, J D Boehrer, M E Brickner
1Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas 75216.
Circulation
|July 1, 1992
概括
慢性可卡因滥用与左心室缩 (LVH) 有关. 患有LVH的可卡因滥用者在运动期间表现出过度的血压升高,这表明可卡因在LVH发育中的作用.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 药物滥用研究 药物滥用研究
背景情况:
- 慢性可卡因滥用经常与正常静止血压的个体的左心室缩 (LVH) 相关.
- 可卡因诱导的LVH与心血管对运动反应之间的关系尚不清楚.
研究的目的:
- 为了调查慢性可卡因滥用者与LVH在跑步机运动期间是否表现出夸张的压力反应.
- 探索运动血压升高对可卡因使用者的LVH病变发生的潜在贡献.
主要方法:
- 49名常压慢性可卡因滥用者和年龄/种族匹配的对照进行了布鲁斯协议跑步机运动测试.
- 使用二维回声心脏图来确定左心室质量和 LVH 诊断的后壁厚度.
- 记录了运动时的缩血压峰值;异常被定义为≥210 mm Hg.
主要成果:
- 左心室缩 (LVH) 在33%的可卡因滥用者中存在,而对照组中只有10% (p=0.02).
- 与没有LVH和对照人群相比,患有LVH的可卡因滥用者表现出明显更高的峰值运动系统血压 (p=0.0001).
- 63%患有LVH的可卡因滥用者有异常的峰值运动缩血压 (≥210毫米升).
结论:
- 患有LVH的慢性可卡因滥用者对跑步机运动表现出过度的压力反应.
- 这种对像运动这样的同情刺激的强烈反应可能有助于敏感个体的LVH的发展.
- 研究结果表明,可卡因滥用会使个体易患心血管变化,包括运动引起的高血压和LVH.
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