MMR 疫苗接种和普遍发育障碍:一个病例控制研究.
Liam Smeeth1, Claire Cook, Eric Fombonne
1Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. autism@lshtm.ac.uk
Lancet (London, England)
|September 15, 2004
概括
麻疹-疹-红疹 (MMR) 疫苗接种不会增加自闭症或普遍发育障碍的风险. 这项研究发现MMR疫苗与儿童发育障碍之间没有关联.
科学领域:
- 儿科健康 儿科健康
- 免疫科学 免疫科学
- 神经发育障碍 神经发育障碍
背景情况:
- 由于公众对麻疹-疹-红疹 (MMR) 疫苗接种和自闭症的担忧,疫苗覆盖率有所下降.
- 研究了MMR疫苗接种与自闭症或其他普遍发育障碍之间的潜在关联.
研究的目的:
- 确定MMR疫苗接种是否与自闭症或普遍发育障碍的风险增加有关.
- 解决公共卫生问题,并为疫苗接种政策提供信息.
主要方法:
- 使用英国通用实践研究数据库进行了一项匹配的病例控制研究.
- 包括1294例被诊断患有普遍发育障碍的病例和4469个匹配的对照.
- 对MMR疫苗接种时间相对于诊断的数据进行分析.
主要成果:
- 在MMR疫苗接种和普遍发育障碍之间没有发现统计学意义上的关联 (OR 0.86,95% CI 0.68-1.09).
- 当分析子组时,结果保持一致,包括自闭症诊断和早期疫苗接种.
- 分析还考虑了MMR-自闭症假设在媒体广泛报道之前的时期.
结论:
- 该研究得出结论,MMR疫苗接种与普遍发育障碍的风险增加无关.
- 这些发现支持MMR疫苗与神经发育结果相关的安全性.
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