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相关概念视频

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
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Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

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相关实验视频

Updated: Jul 10, 2026

Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders
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Published on: August 18, 2023

对治疗慢性阻塞性肺病的新药的前景.

Peter J Barnes1, Trevor T Hansel

  • 1National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK. p.j.barnes@imperial.ac.uk

Lancet (London, England)
|September 15, 2004
PubMed
概括
此摘要是机器生成的。

慢性阻塞性肺病 (COPD) 的新疗法正在开发中,针对炎症和结构变化. 这些疗法旨在减缓疾病进展,改善COPD患者的肺部健康.

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科学领域:

  • 肺部医学 肺部医学
  • 药理学 药理学是指药理学的学科.
  • 呼吸道疾病研究 呼吸道疾病研究

背景情况:

  • 目前用于慢性阻塞性肺病 (COPD) 的治疗方法并不能减缓疾病的进展或抑制小气道和肺膜的炎症.
  • 慢性肺炎包括炎症性细胞流入和结构变化,包括肺部破坏和肺气.

研究的目的:

  • 审查目前正在临床开发中的COPD新兴治疗策略.
  • 突出新型药物标和治疗COPD的方法,包括抗炎,抗纤维和肺部保护剂.

主要方法:

  • 审查正在进行的临床试验和COPD药物开发管道.
  • 基于其作用机制对治疗方法的分类,例如针对炎症途径,细胞信号,粘液产生,纤维化和肺部破坏.

主要成果:

  • 几种广泛的抗炎药物 (例如,固酶4抑制剂) 正处于III期开发阶段.
  • 特定疗法向炎症细胞的涌入 (粘附分子,化学因子,TNF-α),细胞信号传递 (p38 MAPK,NF-kappaB),粘液过度产生 (EGFR激酶抑制剂),纤维化 (TGF-β1),以及肺部破坏 (血清蛋白酶抑制剂).
  • 抗氧化剂,iNOS抑制剂和LTB4受体对抗剂也在得到探索.

结论:

  • 针对不同机制的新型治疗药物正在开发中,以解决COPD管理中的未满足需求.
  • 有效的药物输送到外围肺组织,以及经过验证的生物标志物和监测技术,对于推进新的慢性肺炎治疗方法至关重要.