对左心室几何学,壁壁加厚力学和全球stolic 功能的二次合管的重要性
Filiberto Rodriguez1, Frank Langer, Katherine B Harrington
1Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif 94305-5247, USA.
Circulation
|September 15, 2004
概括
切割关 chordae tendineae显著损害左心室 (LV) 缩功能,并改变心脏几何形状. 这项研究强调了这些"坚固"的在维持正常的 LV 结构和性能方面发挥的关键作用.
科学领域:
- 心血管生理学心血管生理学
- 心脏机械学 心脏机械学
- 生物医学工程 生物医学工程
背景情况:
- 中心-心室连续性对于最佳的左心室 (LV) 缩功能至关重要.
- 前侧叶片二阶""在LV功能中的特定作用仍然在很大程度上未被描述.
研究的目的:
- 为了研究前叶片二阶的功能意义在维护LV缩功能和几何学上.
- 量化切割这些动物对全球和区域LV机制的影响.
主要方法:
- 利用绵羊的放射性不透明标记物和珠柱,创建LV, annulus和乳头肌肉的3D模型.
- 获得的血液动力学数据和3D标记图像在手术切割前和之后.
- 计算的预加载可招募的中风工作 (PRSW) 和末缩弹性 (Ees) 用于全球LV功能评估.
- 测量了珠子位移的横向菌株,以评估区域性心肌变形.
主要成果:
- 弦切割导致全球LV缩功能显著下降,以减少Ees和PRSW为证据.
- LV 几何变化,增加了 LV 底部-顶部的长度和后侧乳头肌肉尖端的位移.
- 局部心肌分析显示出扰乱的下心脏菌株,包括纵向和辐射加厚,以及改变的剪切菌株 (微扭).
结论:
- 第二阶段心脏病的破坏显著影响LV几何和肌肉肌肉之间的心肌重塑.
- 变化的局部缩应变模式,包括微扭曲和壁厚,有助于全球缩功能障碍.
- 这些发现凸显了杆管对于维持正常的 LV 结构和整体缩性能的关键重要性.
相关概念视频
01:16Heart Valves
14.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.9K
01:27Mitral Valve Prolapse I: Introduction
1.1K
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
1.1K
01:20Mitral Regurgitation I: Introduction
1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
01:23Mitral Regurgitation II: Clinical Features and Diagnostic Tests
943
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
943
01:22Mitral Stenosis I: Introduction
1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
557
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557