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前庭 natriuretic有助于防止在左心室动脉瘤修复后的晚期重塑
Hiroshi Tsuneyoshi1, Takeshi Nishina, Takuya Nomoto
1Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan.
Circulation
|September 15, 2004
概括
在大鼠中,心房 natriuretic (ANP) 在 LV 修复手术后改善了左心室 (LV) 改造和功能. ANP降低了纤维化和ACE活性,表明其作为术后治疗的潜力.
科学领域:
- 心脏病学 心脏病学
- 心血管外科心血管外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 左心室修复 (LVR) 改善了LV功能,但初步的好处可以通过重塑来限制.
- ангиотензин转化酶 (ACE) 抑制剂可以延长LVR的好处.
- 大心 natriuretic (ANP) 具有 natriuretic 和血管扩张作用,并可能抑制氨酸 - 血管新生素系统.
研究的目的:
- 评估ANP对LVR后左心室重塑,功能和纤维化的影响.
主要方法:
- 患有LV动脉瘤的老鼠接受了LVR.
- 一组接受静脉注射卡佩里提德 (重组α-hANP) 4 周 (LVR+A 组).
- 对照组接受了正常盐水 (LVR组).
- 进行了心声学,血液动力学测量和分子分析.
主要成果:
- 与LVR组相比,LVR+A组显示出更好的LVR重塑和功能.
- 在LVR+A组中,左心室末端透气压和Tau显着较低.
- 在LVR+A组,末性弹性更高.
- 在LVR+A组中,心肌 ACE活性和纤维化诱导因子的mRNA表达下降.
- 组织学分析显示,LVR+A组心肌纤维化减少.
结论:
- 静脉注射ANP对LVR后的LVR重塑,功能和纤维化产生了有益影响.
- 对于接受LV修复手术的患者来说,ANP可能是一个有价值的术后治疗选择.
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