心脏移植接受者的细胞巨乳病毒感染与内皮功能受损有关
Paraskevi Petrakopoulou1, Marion Kübrich, Sinan Pehlivanli
1Medizinische Klinik und Poliklinik I, University Medical Center, Munich-Grosshadern, Germany.
Circulation
|September 15, 2004
概括
心脏移植接受者的细胞巨乳病毒 (CMV) 感染会损害冠状动脉内皮功能,增加心血管风险. 接受CMV阳性供体心脏的CMV阴性接受者显示出更糟糕的结果和内皮功能障碍.
科学领域:
- 心脏病学 心脏病学
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 心脏异体移植血管病变 (CAV) 源于异体移植内皮损伤.
- 细胞巨乳病毒 (CMV) 感染可能通过破坏内皮血管运动反应,导致CAV.
研究的目的:
- 研究CMV感染对心脏移植受体冠状动脉内皮功能的影响.
- 为了将CMV血清状况和感染发作与CAV发育和心血管事件相关联.
主要方法:
- 在183名心脏移植患者中评估了冠状动脉内皮血管功能.
- 与移植前接受者/捐赠者CMV血清学和记录的CMV感染 (CMVpp65Ag+) 相关的功能.
- 根据CMV血清状况分析心血管事件和死亡.
主要成果:
- 接受CMV阳性心脏的CMV阴性患者的无事件时间较短 (8.1与13.3年).
- 在CMV血清阴性接受者和血清阳性供体心脏 (P<0.01) 中,心脏内皮细胞功能受损 (P<0.01).
- 记录的CMV感染与更明显的内皮功能障碍和随着时间的推移恶化相关.
结论:
- 冠状动脉病毒感染发作与心脏移植接受者的冠状动脉内皮功能受损有关.
- 接受CMV阳性供体心脏的CMV阴性接受者表现出更差的内皮功能和更高的心血管事件率.
- 冠状动脉病毒感染可能通过加剧冠状动脉内皮功能障碍来加速全移植失败.
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