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高剂量的阿司匹林抑制了涉及血栓生成的剪切诱导血小板反应.

C P Ratnatunga1, S F Edmondson, G M Rees

  • 1Department of Cardiothroracic Surgery, St. Bartholomew's Hospital Medical School, London.

Circulation
|March 1, 1992
PubMed
概括
此摘要是机器生成的。

服用75毫克/天的阿司匹林并不能完全预防手术后的血小板过敏反应. 需要更高的阿司匹林剂量 (超过300毫克/天) 来抑制剪切诱导的血小板反应,这表明除了血栓素抑制之外的机制.

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科学领域:

  • 心血管药理学心血管药理学
  • 血小板生物学 血小板生物学

背景情况:

  • 通过循环氧基因酶抑制和前列腺素合成,阿司匹林已知的作用机制不足以解释其所有影响.
  • 关于阿司匹林的综合药理作用,仍有很多问题没有得到答案.

研究的目的:

  • 为了研究不同的阿司匹林剂量对冠状动脉旁路手术后患者的血小板活性的影响.
  • 探索阿司匹林对剪切诱导的血小板反应的影响.

主要方法:

  • 在手术后每天服用75毫克阿司匹林的294名患者中评估了血小板血栓素形成和全血聚合.
  • 患者与健康对照组的血小板活性比较.
  • 90名患者的阿司匹林剂量增加到300毫克/天,并重新测试了反应性.
  • 给正常人服用一次600毫克阿司匹林剂量,并评估剪切诱导的血小板反应.

主要成果:

  • 75毫克/天的阿司匹林在80%的患者中不完全阻止了血小板血栓素的形成,这些患者与对照组相比表现出显著的高反应性.
  • 将阿司匹林剂量增加到每天300毫克显著降低了血小板反应性 (p = 0.0008).
  • 维持每天75毫克的患者没有改变血小板活性.
  • 一次600毫克的阿司匹林剂量在健康受试者中显著抑制了剪切诱导的血小板反应.

结论:

  • 阿司匹林对血小板对剪切力的反应的影响需要更高的剂量 (超过300毫克/天).
  • 这种剪切诱导效应的机制可能与阿司匹林干扰血栓素形成的机制不同.