新皮层内部神经元的长期自我抑制,由内分泌素介导
Alberto Bacci1, John R Huguenard, David A Prince
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
Nature
|September 17, 2004
概括
低值尖端 (LTS) 内神经元通过内大麻素表现出一种新的,长期的自我抑制. 这种由发射触发的机制改变了大脑皮层中神经元刺激能力和突触强度.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 突触性可塑性 突触性可塑性
背景情况:
- 新皮层的GABA活性内核子对皮层网络功能至关重要,它们介导抑制和振荡.
- 快速激增 (FS) 内神经元通过自传递表现出快速的自我抑制.
- 研究了低值尖峰 (LTS) 内神经元,一个独特的内神经元亚型,研究了它们的自我抑制机制.
研究的目的:
- 为了研究LTS新皮层内部神经元的自我抑制机制.
- 描述LTS内部神经元自我抑制的持续时间,离子基和药理性质.
- 阐明LTS内部神经元自我抑制对皮质网络活动的功能后果.
主要方法:
- 在老鼠新皮层内部神经元中的电生理记录.
- 细胞内 ([Ca2+]) 的测量.
- 使用大麻素受体抗剂AM251.1.的药理学阻塞.
主要成果:
- 与FS内部神经元不同,LTS内部神经元表现出缓慢,突出的超极化,由增加的K+通道导电量介导.
- 这种自我抑制取决于细胞内的增加,持续数分钟.
- 该效应被AM251阻断,表明内源性大麻素通过自身隐性信号传递进行中介.
- 这种由内分泌大麻素介导的自我抑制有选择地准金字塔神经元的树突.
结论:
- 在LTS内部神经元中,使用一种独特的,持久的内分泌大麻素介导的自我抑制机制.
- 这一过程显著改变了LTS神经元的内在刺激能力.
- LTS网络的调制会影响金字塔神经元中的谷氨酸中介突触强度,对皮质功能和功能障碍有影响.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Calcium Ion Concentration Mechanism
If over time, all...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Desensitization and Tachyphylaxis
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Several...


