炎症暴露和人类寿命的历史变化
Caleb E Finch1, Eileen M Crimmins
1Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA. cefinch@usc.edu
概括
在一生中减少对传染病和炎症的暴露,一个队列机制,显著降低了老年死亡率. 早期的死亡率强烈预测了后来的生活结果,这表明了持久的"队列发病现象".
科学领域:
- 人口统计学 人口统计学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 预期寿命的历史增长往往归因于医学和公共卫生方面的进步.
- 一个基于队列的机制,涉及减少终身炎症暴露,尚未完全探索.
研究的目的:
- 调查减少终身暴露于传染病和炎症在老年死亡率历史下降中的作用.
- 检查出生队伍中早期死亡率和随后死亡率之间的关联.
主要方法:
- 从1751年起对瑞典出生队伍的分析.
- 在特定的出生队伍中,对整个寿命内的死亡率模式的检查.
主要成果:
- 在相同的队列中,在早期死亡率和随后死亡率之间发现了强烈的关联.
- 这表明一种持续的炎症过程,称为"队列发病现象型",起源于生命早期.
结论:
- 减少一生对炎症的暴露,一个队列效应,是减少老年死亡率的重要贡献者.
- "队列发病现象型"强调了早期炎症过程对后期健康结果的长期影响.
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