不同的Haemophilus influenzae型b联合疫苗引起的抗体的毒性和杀菌活性. 疫苗研究小组的研究

Y Schlesinger1, D M Granoff

  • 1Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Mo.

JAMA
|March 18, 1992
PubMed
概括

新的Haemophilus influenzae b型 (Hib) 结合疫苗,Oligo-CRM和PRP-T,引起的抗体激烈度比PRP-OMPC更高. 较高的狂热性抗体在补充介导的杀菌活性中表现出更大的效力,这表明狂热性对疫苗有效性至关重要.

相关概念视频

Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Cross-reactivity00:42

Cross-reactivity

Overview
Vaccinations01:51

Vaccinations

Overview
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...