在海马单元电路中,一个依赖频率的从抑制到激发的开关
Masahiro Mori1, Mathias H Abegg, Beat H Gähwiler
1Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. mori@hifo.unizh.ch
Nature
|September 24, 2004
概括
海马的纤维可以通过失联通路抑制CA3金字塔细胞. 这种抑制信号随着发射频率的增加而转换为激发,揭示了信息处理的新奇突触机制.
科学领域:
- 神经科学是一个神经科学.
- 突触性可塑性 突触性可塑性
- 计算神经科学是一种神经科学.
背景情况:
- 海马对于记忆和认知至关重要.
- 传统上被视为一个三突触刺激电路.
- 纤维输入到CA3是三突触通路的关键.
研究的目的:
- 研究纤维输入CA3金字塔细胞中的作用.
- 确定纤维是否介导激发或抑制.
- 探索发射频率对突触反应极性的影响.
主要方法:
- 从连接的细胞对在老鼠内-海马片培养物中进行记录.
- 在牙状颗粒细胞中唤起单一作用潜力.
- 分析CA3金字塔细胞中的突触反应.
主要成果:
- 牙状颗粒细胞中的单一作用电位在CA3金字塔细胞中引起净抑制.
- 不同突触的前进抑制取代了单突触刺激.
- 增加的前突触触发频率将反应从抑制转变为激发.
结论:
- 纤维输入可以调解抑制和激发.
- 基于突触前射击频率的突触响应极性开关.
- 这种动态切换是一种新的突触机制,对海马信息处理至关重要.
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