测量血液中的脂质. 变化和实用的实用性
G R Cooper1, G L Myers, S J Smith
1Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Atlanta, GA 30333.
JAMA
|March 25, 1992
概括
生物和分析差异显著影响血清脂质水平和冠状动脉疾病风险. 了解这些变化有助于估计患者的真正胆固醇,并指导测试频率.
科学领域:
- 临床化学 临床化学
- 心血管疾病风险评估心血管疾病风险评估
- 生物统计学 生物统计学
背景情况:
- 血清脂和脂蛋白水平是冠心病 (CHD) 风险的关键指标.
- 显著的生物和分析变化可能会影响这些测量的准确性.
- 解释脂质检测结果需要了解变化的来源和大小.
研究的目的:
- 量化血清脂和脂蛋白水平变化的主要生物和分析来源.
- 评估这些变异对心脏病风险的影响.
- 提供一种估计个体内变化的方法,并确定准确评估胆固醇所需的样本数量.
主要方法:
- 对300多篇关于脂质变异来源的出版物的系统审查.
- 根据标准化条件,明确的结果和可接受的实验设计选择研究.
- 利用来自标准化实验室的定量测量来确定代表性脂质水平.
主要成果:
- 在分析前的变化 (行为,临床,采样) 约占脂质测量总变化的60%.
- 提出了一种定性方法来估计使用2-3个序列标本的个体内生物变异.
- 统计分析证实了数据的可靠性,尽管估计方法提供了定性结果.
结论:
- 预分析因素是个体脂质测量变化的主要来源.
- 医生可以使用所介绍的技术来估计患者特定的变化,并确保遵守国家胆固醇教育计划 (NCEP) 的指导方针 (个体内变化系数<5.0%).
- 一个国家参考方法网络旨在解决脂质检测中的分析挑战.
相关概念视频
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The Brachial Artery: Primary Site for Blood Pressure Measurement
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Monitoring Both Arms:
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Monitoring Both Arms:
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