母亲的摄入量和后代的血压
Matthew W Gillman1, Sheryl L Rifas-Shiman, Ken P Kleinman
1Department of Ambulatory Care and Prevention, Harvard Medical School/Harvard Pilgrim Health Care, Boston, Mass 02215, USA. matthew_gillman@hms.harvard.edu.
Circulation
|September 29, 2004
概括
孕妇在怀孕期间补充可能会降低后代的血压. 这一发现表明,通过产前营养来预防儿童未来高血压的潜在策略.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 关于母亲在怀孕期间的摄入量如何影响后代血压的数据有限.
- 了解这一代际联系对于长期的心血管健康至关重要.
- 维瓦项目是一个正在进行的美国前性队列研究,调查影响儿童健康的因素.
研究的目的:
- 为了研究孕妇在怀孕期间摄取的摄入量与六个月大后代血压之间的联系.
- 为了确定饮食中的或补充摄入量是否对婴儿血压有差异性影响.
- 探索这种关系的潜在修饰因素,如母亲的维生素D和摄入量.
主要方法:
- 分析了Project Viva队列中的936名婴儿的4091次血压测量结果.
- 评估母亲的饮食和补充摄入量,通过食物频率问卷在怀孕的第二个三个月.
- 混合模型用于估计母亲摄入量对婴儿缩血压的影响,并对各种共同变量进行调整.
主要成果:
- 平均每天母亲的摄入量为1494毫克 (1230毫克来自食物,264毫克来自补充剂).
- 随着从食物中增加饮食摄入量,没有观察到婴儿缩血压的显著趋势 (P=0.62).
- 在完全调整后,与母亲补充摄入量 (P=0.006) 相关的是婴儿缩血压显著下降 (-3.0 mm Hg每500 mg增量).
结论:
- 在怀孕中期,母亲的补充摄入量可能与六个月后后代的血压降低有关.
- 这些发现表明,补充可能是帮助预防下一代高血压的策略.
- 第一个三个月的摄入量没有显示出与后代血压的联系.
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