在大麻素-1受体上起作用的内分类大麻素调节高血压中心血管功能
Sándor Bátkai1, Pál Pacher, Douglas Osei-Hyiaman
1Laboratory of Physiologic Studies, National Institute on Alcohol Abuse & Alcoholism, National Institutes of Health, Bethesda, Md 20892-8115, USA.
Circulation
|September 29, 2004
概括
内分类大麻素,像安纳米德一样,有助于调节高血压的血压. 通过阻断降解来增强它们的作用,使高血压大鼠的血压和心脏功能正常化.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 内分类固醇是具有已知的低血压和心脏抑郁作用的脂质介质.
- 内分泌大麻素系统在心血管调节中的作用,特别是高血压,需要进一步研究.
研究的目的:
- 研究内分泌系统在高血压中调节心血管功能的作用.
- 在高血压模型中,确定调节内分泌类大麻素活性是否会影响血压和心脏表现.
主要方法:
- 研究是在自发高血压大鼠 (SHR) 和正常血压的Wistar-Kyoto大鼠中进行的.
- 治疗包括大麻素-1受体 (CB1) 抗剂,脂肪酸胺基酶 (FAAH) 抑制剂以防止安纳米德降解,以及CB1激动剂.
- 测量包括血压,左心室收缩性能和血管阻力.
主要成果:
- 在SHR中,CB1抗剂增加了血压和心脏收缩性.
- 抑制安纳米德降解降低了SHR中的血压,心脏收缩性和血管阻力,使其达到正常压力水平.
- 这些效应被CB1抗剂阻断,并没有在正常紧张的老鼠中观察到.
- 与正常血压大鼠相比,CB1激动剂在SHR中显示出更大的低血压效应.
- 在SHR的心脏和大动脉内皮中,CB1受体表达升高.
结论:
- 内大麻素在高血压状态下对心脏收缩性产生强力抑制作用.
- 通过抑制水解来增强内源性安纳米德的CB1介导作用,可以使血压正常化.
- 内分泌大麻素系统是治疗高血压的有前途的治疗点.
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