慢性冠状动脉全封闭的附带循环的增长因素:与封闭的持续时间和附带功能的关系
Gerald S Werner1, Enrico Jandt, Andreas Krack
1Clinic for Internal Medicine I, Friedrich-Schiller-University Jena, Jena, Germany. gerald.werner@med.uni-jena.de.
Circulation
|September 29, 2004
概括
在冠状动脉疾病中释放的基本纤维细胞生长因子 (bFGF) 与闭塞持续时间和附带功能相关. 这突出了bFGFF的重点.
科学领域:
- 心血管生物学 心血管生物学
- 干预心脏病学 干预心脏病学
- 分子医学是分子医学.
背景情况:
- 尽管对动物进行了研究,但对冠状动脉附带功能的生长因子作用的人类数据有限.
- 冠状动脉附带循环对于在慢性全闭症 (CTO) 中维持血液流动至关重要.
研究的目的:
- 研究CTO患者的特定生长因子和附带功能之间的关系.
- 评估阻塞持续时间,剪切应力和糖尿病对附带动脉生长因子水平的影响.
主要方法:
- 在104名CTO患者中使用冠心内多普勒和压力记录对附带功能的侵入性评估 (附带电阻指数,R(Coll)).
- 在附带血液和全身循环中测量生长因子 (bFGF,MCP-1,TGF-β,PlGF,TNF-alpha).
- 分析生长因子度,闭塞持续时间,剪切压力和患者人口统计 (例如糖尿病) 之间的相关性.
主要成果:
- 与主动脉相比,附带动脉中发现了基础纤维细胞生长因子 (bFGF) 度的升高,特别是在最近的闭塞 (2-12周).
- bFGF水平与抵押抵押阻力 (R(Coll) 有显著的相关性,这表明更高bFGF的抵押功能更好.
- 单细胞化疗蛋白-1 (MCP-1),转化生长因子-β (TGF-β) 和胎盘生长因子 (PlGF) 的附带因素也增加,受剪切应激的影响.
- 糖尿病患者比非糖尿病患者表现出较低的bFGF和较高的MCP-1水平.
结论:
- 在CTO中,bFGF连续释放到附带物中与闭塞持续时间和附带功能密切相关,这表明了治疗潜力.
- 切割压力和糖尿病被确定为调节增长因子在附带循环中的释放的因素.
- 这些发现为人类冠状动脉附带细胞发育和功能背后的分子机制提供了新的见解.
相关概念视频
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
3.1K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.1K
Factors Influencing Microbial Growth: Osmolarity
992
Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
992
Factors Influencing Microbial Growth: Temperature
1.4K
Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.4K
Factors Influencing Microbial Growth: pH
1.3K
Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.3K
Coronary Circulation
7.6K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.6K
Role of Hematopoietic Growth Factors
4.0K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
4.0K


