氨基作为"兼容"的离子发生器在氨基性C-C键形成中
Michinori Suginome1, Lars Uehlin, Masahiro Murakami
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, PRESTO, Japan Science and Technology Corporation, Katsura, Kyoto 615-8510, Japan. suginome@sbchem.kyoto-u.ac.jp
Journal of the American Chemical Society
|October 14, 2004
概括
氨基能有效地产生离子,用于曼尼赫式反应. 大量的aminoboranes使得自由二次胺在与化物和基乙醇的三元合中可以使用.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
背景情况:
- 氨基是有效的iminium离子发生器.
- 曼尼赫类反应对于形成碳-碳键至关重要.
研究的目的:
- 探索在曼尼赫反应中使用重的氨基.
- 为了使自由二次胺在三元合中直接使用.
主要方法:
- 使用含有大量氨基基群的氨基 (例如,二胺).
- 反应的化物,西乙和自由二次氨基.
主要成果:
- 氨基作为高效和温和的离子发生器.
- 大量的aminoboranes促进了自由二次胺的成功结合.
- 证明了具有广泛适用性的三组分曼尼赫反应.
结论:
- 大量的aminoboranes是aminative合反应的宝贵工具.
- 这种方法为复杂分子提供了温和而高效的途径.
- 使用易于获得的二次胺扩大了曼尼赫反应的范围.
相关概念视频
00:26Hydrogen Bonds
Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
03:07Electron Affinity
The electron affinity (EA) is the energy change for adding an electron to a gaseous atom to form an anion (negative ion).
03:01Halogens
Group 17 elements, known as halogens, are nonmetals. At room temperature, fluorine and chlorine are gases, bromine is a liquid, and iodine a solid. Astatine is a highly unstable radioactive element, so currently, most of its properties are unknown due to its short half-life. Tennessine is a synthetic element also predicted to be in this group.
02:45Valence Bond Theory
Overview of Valence Bond Theory
03:35Hybridization of Atomic Orbitals II
sp3d and sp3d 2 Hybridization
01:04Hydrogen Bonds
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...