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Updated: May 5, 2026

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
08:50

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets

Published on: July 3, 2018

16.9K

移除Ca2+通道β3亚单元可以增强Ca2+振荡频率和胰岛素外细胞形成

Per-Olof Berggren1, Shao-Nian Yang, Manabu Murakami

  • 1The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S-17176 Stockholm, Sweden. per-olof.berggren@molmed.ki.se

Cell
|October 14, 2004
PubMed
概括

β3亚单元对葡萄糖诱导的胰岛素分泌进行负面调节. 通过增加振荡和胰岛素释放,在小鼠中去除这种子单元可以改善葡萄糖平衡,这表明了新的糖尿病治疗点.

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Imaging Calcium Dynamics in Subpopulations of Mouse Pancreatic Islet Cells

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Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices

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相关概念视频

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Insulin Secretory Vesicles01:05

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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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