在接受冠状动脉血管造影或干预的患有功能障碍的患者中,酸可以预防对比介导的病
Konstantinos Spargias1, Elias Alexopoulos, Stamatis Kyrzopoulos
1Department of Cardiology, Onassis Cardiac Surgery Centre, 356 Syngrou Ave, 176 74, Athens, Greece. spargias@ocsc.gr
Circulation
|October 20, 2004
概括
口服 Askorbic 酸 (维生素 C) 在接受冠状动脉手术的患者中可以预防损伤. 这种抗氧化剂在随机试验中降低了对比介导病的发生率,这表明它对对比诱导的损伤有保护作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对比剂可以通过活性氧物种诱导功能障碍.
- 乙半氨酸已经显示出预防对比诱导性脏病的潜力,但其他抗氧化剂仍未得到研究.
研究的目的:
- 评价阿斯科布酸作为预防药物对进行冠状动脉血管造影或干预的患者的对比介导性病的疗效.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及231名高风险患者 (血清肌素>或=1.2 mg/dL).
- 患者接受了口服阿斯科布酸 (3g手术前,2g手术后) 或安慰剂.
- 对比介导性脏病被定义为在术后2-5天内血清肌素>或=0.5毫克/分升或>或=25%的增加.
主要成果:
- 与对比剂介导的神经病变发生在接受 Askorbic 酸的患者中的 9%,与安慰剂组中的 20% 相比 (OR,0.38;P=0.02).
- 血清肌素的平均增加在安慰剂组明显大于与酸组相比 (P=0.049).
结论:
- 在接受冠状动脉手术的高风险患者中,预防性口服 Askorbic 酸的使用可能会保护他们免受对比介导的神经病变.
- 阿斯科布酸代表了一种潜在的治疗策略,以减轻对比引起的损伤.
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