在静脉静脉血栓溶解基础动脉封闭后的长期结果
Perttu J Lindsberg1, Lauri Soinne, Turgut Tatlisumak
1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. perttu.lindsberg@hus.fi
JAMA
|October 21, 2004
概括
针对基底动脉封闭 (BAO) 的用高高酶进行静脉内血栓溶解,显示了与内血管方法相比的生存率和功能结果. 进一步的随机试验是必要的,以证实这些发现对BAO治疗.
科学领域:
- 神经学 神经学
- 血管神经学 血管神经学
- 干预神经病学 干预神经病学
背景情况:
- 基底动脉封闭 (BAO) 是一种罕见的疾病,具有显著的发病率和死亡率.
- 目前的治疗,静脉内血栓溶解,仅限于专门的中心.
研究的目的:
- 为了评估BAO患者使用静脉输血栓解压疗法治疗的结果.
主要方法:
- 一项针对50名血管图学证明的BAO患者连续接受1小时内静脉输入高血 (0.9毫克/公斤) 治疗的研究.
- 评估的结果包括基底动脉再通道化 (MR血管造影) 和临床状态 (修改的兰金尺度,巴特尔指数) 在3个月和长期随访.
主要成果:
- 在52%的患者中实现了再通道化.
- 3个月后,40%的患者死亡,16%的患者严重残疾,24%的患者实现了独立.
- 长期随访 (中位数为2.8年) 显示30%的良好结果和46%的死亡率.
结论:
- 对BAO的静脉输入高位素证明了与内血管治疗相比的存活率,再通道化和功能结果.
- 建议进行随机试验,直接比较静脉内血栓溶解与内血管方法的BAO.
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