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DNA末端切除,同源重组和DNA损伤检查点激活需要CDK1

Grzegorz Ira1, Achille Pellicioli, Alitukiriza Balijja

  • 1Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, USA.

Nature
|October 22, 2004
PubMed
概括

循环素依赖激酶1 (CDK1) 对于激活DNA损伤检查点和在酵母中的双链断裂 (DSB) 后同源重组修复至关重要. CDK1还促进DNA末端切除,这是修复过程中的关键步骤.

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