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在有机溶剂中制备高度单分散的微米大小颗粒的一步制备

Hua Hu1, Ronald G Larson

  • 1Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2136, USA. huhuadce@umich.edu

Journal of the American Chemical Society
|October 28, 2004
PubMed
概括

研究人员开发了一种简单的,单步方法,通过分散聚合制造来制造大型,均的聚甲基甲酸 (PMMA) 颗粒. 这种技术产生了微米大小的PMMA,具有高单分散性,促进了聚合物合成.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...