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Updated: Jul 12, 2026

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
08:27

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Published on: April 10, 2018

同源重组产生T环大小的删除在人类端粒

Richard C Wang1, Agata Smogorzewska, Titia de Lange

  • 1Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Cell
|October 28, 2004
PubMed
概括

一种突变的TRF2蛋白 (TRF2DeltaB) 抑制了端粒末端的结合,但导致了DNA删除. 这些取消取决于XRCC3,形成了端粒圆,表明同源重组 (HR) 影响端粒长度和完整性.

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