有证据表明,死因于大动脉和 mitra 门疾病的遗传因素
Benjamin D Horne1, Nicola J Camp, Joseph B Muhlestein
1Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108-1266, USA. benjamin@genepi.med.utah.edu
Circulation
|November 3, 2004
概括
遗传因素有助于因非风湿性甲状腺膜和大动脉膜疾病导致的死亡. 这项研究发现这些疾病的家族风险增加,特别是在早期发病的情况下,这表明遗传因素.
科学领域:
- 心血管遗传学 心血管遗传学
- 流行病学 流行病学
- 医学遗传学 医学遗传学
背景情况:
- 在美国,心脏膜疾病每年导致超过42,000人死亡.
- 对膜疾病死亡率的遗传贡献在很大程度上是未知的.
- 这项研究研究了由于特定的膜疾病而导致的死亡的家族聚合.
研究的目的:
- 评估非风湿性大动脉和 mitra 门疾病死亡的亲属性.
- 评估遗传学在膜疾病死亡率中的作用.
- 为了确定膜疾病死亡中的遗传模式.
主要方法:
- 利用犹他州人口数据库,将家谱数据与超过25万份死亡证明联系起来.
- 分析了非风湿性大动脉 (n=932), mitra (n=1165) 和所有膜疾病 (n=2504) 的死亡人数.
- 评估了第一级和第二级亲属的家族相对风险 (FRR),并使用了家族关系的家谱指数.
主要成果:
- 在一级 (FRR,2.55) 和二级 (FRR,1.67) 亲属中,观察到额头门死亡的家族相对风险增加 (FRR).
- 亲属关系分析的基因指数显示所有膜疾病组的显著过度相关性 (P<0.001).
- 过度的亲属关系扩展到距离的亲戚对米特拉和大动脉死亡,特别是在早期发病的病例.
结论:
- 由于非风湿性头膜和大动脉膜疾病的死亡,表现出显著的家族聚类,特别是在早期发病的病例中.
- 这些发现表明,膜疾病死亡率的基础上存在着相当大的遗传成分.
- 未来的研究应该优先考虑基因发现,以阐明这些疾病的遗传基础.
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