与肥胖相关的左心室心肌特征的改变
Chiew Y Wong1, Trisha O'Moore-Sullivan, Rodel Leano
1University of Queensland, Brisbane, Australia.
Circulation
|November 3, 2004
概括
肥胖与亚临床心脏变化有关,即使没有确诊的心脏病. 较高的身体质量指数 (BMI) 与左心室 (LV) 功能的减少以及超重和肥胖个体的心肌反射率的增加有关.
科学领域:
- 心脏病学 心脏病学
- 肥胖医学 肥胖医学
- 医疗成像医学成像
背景情况:
- 肥胖是心力衰竭的一个已知的危险因素.
- 体重对心脏结构和功能的独立影响,与相关疾病分开,需要进一步研究.
- 与体重指数 (BMI) 和胰岛素水平相关的亚临床心肌乱并未得到充分证实.
研究的目的:
- 研究身体质量指数 (BMI) 和胰岛素水平与亚临床心肌乱之间的关联.
- 为了确定超重和肥胖是否与其他健康状况独立的心脏结构和功能变化有关.
主要方法:
- 心声学,包括心肌多普勒 (心缩[sm]和早期透析速度[em]),应变,应变速率成像和组织特征 (集成反射散射的循环变化[CVIB],校准集成反射散射[cIB]).
- 该研究包括109名超重或肥胖患者和33名参考患者 (BMI <25 kg/m2).
- 根据平均动脉压,年龄,性别和左心室 (LV) 质量进行调整的分析.
主要成果:
- 较高的BMI与增加的LV质量和壁厚度相关.
- 与基准人群相比,严重肥胖的受试者 (BMI >35) 呈现了 LV 缩和腹功能降低和心肌反射率增加.
- 超重和轻度肥胖的个体表现出类似的功能和反射性变化,尽管明显程度较低;这些与禁食胰岛素水平和运动能力降低相关.
结论:
- 没有明显心脏病的超重个体表现出左心室 (LV) 结构和功能的亚临床变化.
- 这些变化独立于平均动脉压,年龄,性别和 LV 质量等因素而发生.
- 研究结果表明,高BMI甚至在心脏病临床表现之前就会导致心肌动脉障碍.
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