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Updated: Jul 25, 2026

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
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通过立体匹配进行线程定向:一个设计的反平行卷轴-卷轴剪切器

Nathan A Schnarr1, Alan J Kennan

  • 1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

Journal of the American Chemical Society
|November 4, 2004
PubMed
概括

研究人员通过战略性地重新定位氨基酸替代物来设计了一种新的反平行线圈-线圈异构聚合物. 这种新的组件表现出与其平行对应物相比的稳定性,为蛋白质结构控制提供了新的见解.

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Protein Folding01:22

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Induced-fit Model01:13

Induced-fit Model

Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
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Cooperative Allosteric Transitions01:58

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...