在社区居住的老年人中,每年对流感和死亡风险进行再接种疫苗
A C G Voordouw1, M C J M Sturkenboom, J P Dieleman
1Pharmaco-epidemiology Unit, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
JAMA
|November 4, 2004
概括
每年接种流感疫苗可以显著降低老年人死亡风险. 一贯的再接种提供了更大的保护,预防死亡,提高老年人群的生存率.
科学领域:
- 老年学是指老年学的学科.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究证实了流感疫苗接种的有效性.
- 关于每年接种一次流感疫苗的临床益处的数据有限.
- 老年人是接种疫苗战略的关键人口.
研究的目的:
- 评估年度流感再接种疫苗对社区老年人死亡率的影响.
- 量化与连续接种流感疫苗相关的死亡率降低.
- 调查流感疫苗接种在降低老年人全因死亡率方面的作用.
主要方法:
- 在荷兰 (1996-2002) 使用IPCI数据库进行基于人口的队列研究.
- 包括65岁及以上的社区居民.
- 对流感疫苗接种和其与所有原因死亡率的累积暴露的分析,对共变量进行调整.
主要成果:
- 第一次接种流感疫苗显示,死亡风险减少了10%,但不显著.
- 每年重新接种疫苗与死亡风险显著降低24%有关.
- 再接种疫苗与第一次接种疫苗相比,每年死亡风险降低了15%,在流行病期间的好处更大.
结论:
- 每年接种流感疫苗与老年人群全因死亡率的降低有关.
- 接种流感疫苗的好处在老年人中尤为明显.
- 流感疫苗接种是预防老年人死亡的有效策略,持续的再接种增强了保护.
相关概念视频
Vaccinations
44.0K
Overview
44.0K
Pneumonia V: Nursing management and Prevention
4.1K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.1K
Drug Dosing: Geriatric Patients
392
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
392
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
352
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
352
Pharmacodynamics in Geriatric Patients: Effects of Age
366
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
366
Influenza
79
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
79


