在年轻女性中低度状内皮层病变的回归
Anna-Barbara Moscicki1, Stephen Shiboski, Nancy K Hills
1Department of Pediatrics, University of California, San Francisco, CA, USA. annam@itsa.ucsf.edu
Lancet (London, England)
|November 9, 2004
概括
大多数患有低度状内皮病变 (LSIL) 的年轻女性经历了回归,特别是当人类乳头瘤病毒 (HPV) 没有被检测到时. HPV检测可以帮助监测青少年的LSIL进展.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 低度状内皮损伤 (LSIL) 是年轻女性常见的发现.
- 了解LSIL回归对于适当的管理和减少不必要的干预至关重要.
研究的目的:
- 为了确定LSIL回归在女性青少年的概率.
- 为了确定与LSIL回归相关的因素.
主要方法:
- 一项纵向研究跟踪了187名被诊断患有LSIL的女性青少年 (13至22岁).
- 参与者每4个月进行一次定期的细胞检查,肠镜检查和HPVDNA检测.
- 回归被定义为至少连续三次正常的巴普素检查.
主要成果:
- 整体回归概率在12个月后为61%,在36个月后为91%.
- 在回归和基线HPV状态,性行为或其他生活方式因素之间没有发现任何关联.
- 目前的HPV状况是与回归率相关的唯一重要因素.
结论:
- 高的LSIL回归率支持年轻女性的观察管理.
- 阴性HPV状态与回归相关,表明HPV测试在监测LSIL中的实用性.
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