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相关概念视频

Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

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相关实验视频

Updated: Jul 16, 2026

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
08:38

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用eppin免疫接种的雄性子的可逆免疫避孕.

M G O'rand1, E E Widgren, P Sivashanmugam

  • 1Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. morand@unc.edu

Science (New York, N.Y.)
|November 13, 2004
PubMed
概括

研究人员使用一种名为Eppin.in的蛋白质开发出一种可逆的男性避孕药. 用Eppin对雄性子进行免疫接种导致不孕,在免疫接种停止后,生育能力恢复,显示出人类使用的潜力.

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科学领域:

  • 生殖生物学 生殖生物学
  • 免疫学 免疫学 免疫学
  • 避孕药的发展与开发

背景情况:

  • 对于男性来说,生育控制的选择有限,因此需要男性避孕药.
  • 有效,安全和可逆的男性避孕药对于全球计划生育至关重要.

研究的目的:

  • 研究Eppin免疫避孕在男性非人类灵长类动物中的潜力.
  • 评估基于Eppin的男性避孕药的疗效和可逆性.

主要方法:

  • 雄性非人类灵长类动物 (Macaca radiata) 用Eppin免疫接种,Eppin是一种特定于丸和脊髓的蛋白质.
  • 测量了针对Eppin的抗体标位.
  • 免疫接种前,接种期间和接种后评估生育能力.

主要成果:

  • 在9名 (78%) 免疫接种的男性中,有7名患有Eppin.的高抗体标位.
  • 所有具有高抗埃平因位数的男性都变得不育.
  • 在7名 (71%) 具有高抗Eppin标位的男性中,有5名在停止免疫接种后恢复了生育能力.

结论:

  • 使用Eppin的男性免疫避孕是一种有效和可逆的方法.
  • 这种方法显示出开发作为人类避孕药的前景.