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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

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相关实验视频

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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

在急性心肌梗塞后,大脑尿性的过度表达促进了中性粒细胞透和心脏基质金属蛋白酶-9的表达.

Rika Kawakami1, Yoshihiko Saito, Ichiro Kishimoto

  • 1Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Circulation
|November 17, 2004
PubMed
概括
此摘要是机器生成的。

在小鼠中,大脑尿性 (BNP) 的升高促进了中性粒细胞透和肌肉内心梗塞 (MI) 后的矩阵金属蛋白酶-9 (MMP-9) 活性. 这表明,BNP影响了早期的伤口愈合和MI后的细胞外矩阵重塑.

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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

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Published on: June 14, 2016

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科学领域:

  • 心脏病学 心脏病学
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 系统性内西里提德 (复合人脑尿性 - - BNP) 改善了失补偿心脏中的血液动力学.
  • 在急性心肌梗塞 (MI) 中,BNP可能提供治疗效益.
  • 这项研究研究了BNP在左心室重塑和治疗后心脏病的作用,使用BNP转基因 (BNP-Tg) 的小鼠.

研究的目的:

  • 确定血BNP的升高如何影响心脏病发作后的左心室重塑和愈合.
  • 为了研究BNP对中性粒细胞透和矩阵金属蛋白酶 (MMP) 表达在心脏病发作区域的影响.

主要方法:

  • 在MI后的BNP-Tg小鼠和非转基因 (非Tg) littermates中,中性粒细胞透和MMP-9表达/激活的比较.
  • 对MMP-2和MMP-9的基因表达和生殖图学活性进行分析.
  • 双重免疫染以确定MMP-9来源;评估多克西环素对中性粒细胞透的影响.

主要成果:

  • 在心脏病发作后3天,BNP-Tg小鼠在心脏病发作的区域中显著增加了中性粒细胞的透.
  • 与非Tg小鼠相比,MMP-9的基因表达和活性在BNP-Tg小鼠中显著更高.
  • 中性粒细胞被确定为MMP-9的主要来源,而多西环素没有影响中性粒细胞透.

结论:

  • 血BNP升高增加中性粒细胞透到心脏病发作后的心脏病发作区域.
  • 布朗尼增加了透中性粒细胞产生的MMP-9的活性.
  • 在急性心脏病发作后,BNP在细胞外矩阵重塑和早期伤口愈合中发挥着至关重要的作用.