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Updated: Dec 31, 2025

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
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基于雌激素受体-β选择性连接体的结构设计

Eric S Manas1, Rayomand J Unwalla, Zhang B Xu

  • 1Department of Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. manase@wyeth.com

Journal of the American Chemical Society
|November 19, 2004
PubMed
概括

我们使用基于结构的设计优化了雌激素受体-β (ERbeta) 选择性连接体. 微妙的结合口袋差异产生了超过100倍的ERbeta选择性,促进了选择性雌激素受体调节器的发展.

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