有针对性的癌症治疗
1Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, 10833 LeConte Avenue, Los Angeles, California 90095, USA. csawyers@mednet.ucla.edu
Nature
|November 19, 2004
概括
癌症是由于细胞循环调节受损而产生的. 了解分子变化和瘤微环境为有效的癌症治疗提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 癌症的发展基本上与细胞周期进展和分裂的失调有关.
- 涉及调节因素,瘤微环境和细胞应激反应 (例如,DNA损伤) 的复杂相互作用决定了癌细胞的命运 (增殖与亡).
研究的目的:
- 为突出了解癌症分子基础的最新进展.
- 要强调开发基于这些知识的向治疗的潜力.
主要方法:
- 关于癌症调节的当前分子和细胞生物学研究的综述.
- 分析遗传因素,瘤微环境和压力信号通路之间的相互作用.
主要成果:
- 鉴定细胞循环控制中的关键分子干扰,作为瘤发生的核心.
- 阐明复杂的调节网络和微环境线索在癌症进展中的作用.
结论:
- 分子理解的进步为合理设计,有针对性的癌症疗法提供了基础.
- 针对特定的功能障碍分子和途径有望提高治疗效率.
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