塞马福林3E和plexin-D1控制血管模式独立于神经皮林
Chenghua Gu1, Yutaka Yoshida, Jean Livet
1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.
Science (New York, N.Y.)
|November 20, 2004
概括
血红素3E (Sema3E) 和plexin-D1信号指导小鼠血管模式. 这一途径控制了内皮细胞的定位,揭示了独立于神经皮林的血管发育的新机制.
科学领域:
- 发展生物学 发展生物学
- 血管生物学 血管生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 有图案的血管系统对于器官发育至关重要.
- 半氨酸是已知的信号分子,通常需要神经皮林核受体.
研究的目的:
- 为了研究3E (Sema3E) 和plexin-D1在控制小鼠器官生成过程中的血管模式中的作用.
主要方法:
- 在小鼠模型中利用了Sema3E和plexin-D1的遗传切除.
- 检查了内皮细胞的定位和体内血管的发育.
- 研究了神经皮林在Sema3E-plexin-D1信号传输中的必要性.
主要成果:
- 塞马3E作为表达plexin-D1.1的内皮细胞的排斥性提示作用.
- 遗传性Sema3E或plexin-D1的破坏 损害了血管模式.
- 在Sema3E-plexin-D1信号传递功能上,它与神经皮林无关.
结论:
- 确定了一种新型的semaphorin信号通路,控制血管模式.
- 证明Sema3E-plexin-D1信号传递对于内皮细胞引导至关重要.
- 质疑神经皮林在所有语音蛋白信号通路中所谓的强制性作用.
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